Audio Device: Selects which device is used for audio output (e.g computer speakers, or a headset)
Sample Rate: Selects the sample rate for the audio output – typically, computers output at 44,100Hz or 48,000Hz, so they usually offer the best sound quality.
Latency: This represents the length of the buffer used in audio processing. A smaller value results in less delay between the audio and video, however, depending on the hardware used, a value that is too small may cause sound problems.
The equalizer can be used to alter the relative strength of specific frequencies.
Enable cubic interpolation: This option replaces the SNES’ default gaussian interpolation filter with a cubic interpolation filter which can produce better audio.
Disable dynamic sample rate: While a game is running, the video and audio typically slowly drift out of sync. Mesen-S will automatically make adjustments to the audio sample rate while the game is running to keep them in sync. Disabling this option will typically cause sound issues such as crackling.